Oxygen scavenging, NADH oxidase and metronidazole resistance in Helicobacter pylori
نویسندگان
چکیده
منابع مشابه
Metronidazole Resistance of Helicobacter Pylori in Bahrain
Resistance of Helicobacter pylori (HP) to metronidazole (MTZ) is a growing medical problem in various parts of the world. There has been no reports on this problem from our geographic region and the aim of this study is to evaluate the percentage of MTZ resistance among isolates in Bahrain. Out of 72 isolated strains 34 (47.2%) were resistant to MTZ. The resistance among males and females was 5...
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To study whether the capability of horizontal DNA transfer is associated with metronidazole resistance in Helicobacter pylori, a total of 81 clinical isolates were tested for MICs of metronidazole (MTZ). The MIC assays were performed by using the E-test and reconfirmed by the agar dilution method. Natural competence assays were performed by transferring a chloramphenicol acetyltransferase casse...
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Helicobacter pylori resistance to metronidazole was detected in 107 (52.97%) of 202 strains. Twenty (9.85%) strains, 18 of them harboring 23S ribosomal DNA mutations, were resistant to clarithromycin. Metronidazole resistance was associated with female gender. Resistance to metronidazole and resistance to clarithromycin were associated. Increasing clarithromycin resistance rates were observed o...
متن کاملRole of the rdxA and frxA genes in oxygen-dependent metronidazole resistance of Helicobacter pylori.
Almost 50 % of all Helicobacter pylori isolates are resistant to metronidazole, which reduces the efficacy of metronidazole-containing regimens, but does not make them completely ineffective. This discrepancy between in vitro metronidazole resistance and treatment outcome may partially be explained by changes in oxygen pressure in the gastric environment, as metronidazole-resistant (MtzR) H. py...
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Helicobacter Pylori (H. pylori) as a gram-negative bacterium is the most common infection of the gastrointestinal tract, and worldwide it affects the children over three years of age. H. pylori could cause gastrointestinal and extra-intestinal manifestations. Antibiotic resistance can happen primarily and occurs during treatment. We aimed to evaluate the resistance gene of H. pylori obtained fr...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1997
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/39.3.347